Adult Initially 100 or 200 mg, followed by 100 mg every 12 hr. May give two or four 50 mg doses if more frequent doses are preferred, followed by one 50 mg dose every 6 hr. Continue therapy for 1 or 2 days after characteristic symptoms or fever subsides. Syphilis Duration of treatment: 10 or 15 days. Childn ≥13 yr Initially 4 mg/kg followed by 2 mg/kg every 12 hr.
Not for acute throat infections. Avoid use in conjunction w/ penicillin. Not to be used for streptococcal disease treatment unless the organism is demonstrated to be sensitive. May increase risk of dose-related BUN. May aggravate symptoms associated w/ lupus erythematosus. May depress plasma prothrombin activity; regularly monitor patients who are on anticoagulant therapy. Possible interference w/ vit K synthesis by gut microorganisms. Cross sensitization among various tetracyclines; consider potential cross-resistance if expected results are not achieved. Occasional pigmentation of skin, thyroid, bone & teeth when administered for extended periods of time. Possible benign intracranial HTN in adults. Avoid administration of isotretinoin or other systemic retinoids or retinol shortly before, during & after minocycline therapy. Avoid exposure to direct sunlight &/or UV light during treatment. Discontinue treatment at the 1st evidence of skin erythema or discomfort. Possible non-susceptible organism overgrowth (including fungi); discontinue use & institute appropriate therapy if superinfection occurs. Perform culture & sensitivity studies whenever feasible & routinely in suspected streptococcal infections. Patients w/ history of allergy, asthma, hay fever, or urticaria. Darkfield exam should be made from any lesion suggestive of concurrent syphilis before treating patients w/ gonorrhea; repeat serological tests for syphilis mthly for at least 4 mth. Perform periodic lab evaluation of organ systems including hematopoietic, renal & hepatic studies in long-term therapy. Do not give concomitantly w/ antacids containing Al, Ca or Mg & oral Fe prep. Absorption may be delayed by dairy products. May cause headaches, light-headedness, dizziness or vertigo; may affect ability to drive vehicles or use hazardous machinery. Usual oral doses may lead to excessive systemic accumulations & possible hepatic toxicity in the presence of significant renal impairment; determine serum level if therapy is prolonged. Elevated serum minocycline levels can lead to azotemia, hypophosphatemia & acidosis in patients w/ significant renal impairment. Patients w/ hepatic impairment & in conjunction w/ alcohol or other hepatotoxic drugs. Not recommended during pregnancy & lactation; childn <13 yr. Permanent tooth discolouration during tooth development (last 1/2 of pregnancy, infancy & childn <13 yr); enamel hypoplasia. Decreased fibula growth rate in prematures. Risk of bulging fontanels in young infants.
Avoid use w/ penicillin; administration of isotretinoin or other systemic retinoids or retinol shortly before, during & after minocycline therapy. Not for concomitant use w/ antacids containing Al, Ca or Mg & oral Fe prep. Absorption may be delayed by dairy products.
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